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5 METABOLOMICS
5.1 NMR Metabolomics Approach

NMR metabolomics is complementary to LC mass spectrometry-based metabolomics, metabolite profiling and metabolite identification. The NMR metabolomics approach possesses many features and advantages that make it more suitable for some metabolite profiling and metabolite identification studies e.g.

 

  • Universality of metabolite detection: i.e. if a metabolite contains hydrogen, it will be detected

  • The whole biological sample can be analysed in one measurement without chromatographic separation

  • The NMR metabolomics approach has very high analytical reproducibility

  • Molecular identification is relatively easy from databases of authentic material and from analysis of 1D and 2D spectra

  • The process is amenable to the collection of molecular dynamics information

  • Analysis of tissue samples is possible by magic-angle spinning (MAS) NMR

  • Robustness of NMR instrumentation

  • NMR approach requires minimal preparation of samples prior to analysis

 

Instrumenation available available for NMR-based metabolomics analyses include the 700 and 600 MHz spectrometer with high sensitivity cryogenic heads for solution studies plus automated sample changer for metabolomics, ligand screening and metabolite identification.

 

Please contact us for details of our process and a quote.